期刊
ACTA BIOMATERIALIA
卷 6, 期 7, 页码 2732-2739出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2010.01.025
关键词
Chitosan; Quantum dots; Nanocarrier; Controlled drug release
The objective of the study is to describe a new approach of combining quantum dots technology with anti-cancer drug therapy. In this regard, we communicate the preliminary research on the synthesis of blue-light emitting ZnO quantum dots (QDs) combined with biodegradable chitosan (N-acetylglucosamine) for tumor-targeted drug delivery. The results presented here indicate that the proposed new generation of QDs loaded with anti-cancer agents and encapsulated with biocompatible polymer represent a potential platform to deliver tumor-targeted drugs and document the delivery process, if desired. Nontoxic water-dispersed ZnO QDs with long-term fluorescence stability were synthesized by a chemical hydrolysis method, encapsulated with chitosan and loaded with anti-cancer drug. Chitosan enhanced the stability of the QDs because of the hydrophilicity and cationic charge of chitosan. The study points toward the application of water-dispersed ZnO QDs with long-term fluorescence stability for design of new drug release carrier. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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