期刊
ACTA BIOMATERIALIA
卷 6, 期 2, 页码 486-493出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2009.07.021
关键词
Hydrogel; Cyclodextrin; Contact lenses; Ophthalmic delivery; Puerarin
资金
- National Nature Science Foundation of China [50573011, 50673019]
- Hydron Contact Lenses Co. Ltd. (China)
Poly(2-hydroxyethyl methacrylate) hydrogels containing beta-cyclodextrin (pHEMA/beta-CD) have been investigated as a platform for sustained release of ophthalmic drugs. First of all, pHEMA/beta-CD hydrogel membranes and contact lenses were prepared by photopolymerization of HEMA, mono-methacrylated beta-CD (mono-MA-beta-CD) and trimethylol propane trimethacrylate using a cast molding process. The hydrogels were characterized by Fourier transform infrared spectroscopy, equilibrium swelling ratio (ESR) and tensile tester. The results showed that the incorporation of beta-CD in the hydrogels increased the ESR and tensile strength. Then, puerarin was used as a model to evaluate drug loading and in vitro and in vivo release behavior of the pHEMA/beta-CD hydrogels. It was revealed that puerarin loading and in vitro release rate were dependent on beta-CD content in the pHEMA/beta-CD hydrogels. In rabbit eyes the pHEMA/beta-CD hydrogel contact lenses exhibited longer mean residence times (MRTF) of puerarin in tear fluid than that of pHEMA contact lenses and 1% puerarin eye drops. The puerarin concentration in the aqueous humor of rabbit reached a maximum of 0.81 mu g ml(-1) after wearing the pHEMA/beta-CD contact lens, which had been presoaked in 0.802 mg ml(-1) puerarin solution for 4.81 h. Also, the pHEMA/beta-CD contact lenses had a higher drug bioavailability in aqueous humor than puerarin eye drops. The data demonstrate that pHEMA/beta-CD hydrogel contact lenses can effectively deliver puerarin through the cornea. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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