期刊
ACTA BIOMATERIALIA
卷 6, 期 3, 页码 856-863出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2009.08.004
关键词
Bone ingrowth scaffolds; Composite; Hydroxyapatite; Micro-computed tomography; Polyetheretherketone
资金
- Indiana 21st Century Research and Technology Fund
- US Army Medical Research and Materiel Command [W81XWH-06-1-0196]
- Peer Reviewed Medical Research Program [PR054672]
Hydroxyapatite (HA) whisker-reinforced polyetherketoneketone (PEKK) bone ingrowth scaffolds were prepared and characterized. High levels of porosity (75-90%) and HA whisker reinforcement (0-40 vol %) were attained using a powder processing approach to mix the HA whiskers, PEKK powder and a NaCl porogen, followed by compression molding at 350-375 degrees C and particle leaching to remove the porogen. The scaffold architecture and microstructure exhibited characteristics known to be favorable for osteointegration. Scaffold porosity was interconnected with a mean pore size in the range 200-300 mu m as measured by micro-computed tomography HA whiskers were embedded within and exposed on the surface of scaffold struts, producing a microscale surface topography, shown by von Kossa staining and scanning electron microscopy Therefore. HA whisker-reinforced PEKK bone ingrowth scaffolds may be advantageous for orthopedic implant fixation, including interbody spinal fusion. (C) 2009 Acta Materialia Inc Published by Elsevier Ltd All rights reserved
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