期刊
ACTA BIOMATERIALIA
卷 6, 期 6, 页码 1925-1930出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2009.12.001
关键词
Surface modification; PLA scaffold; Peptide adsorption; Hydrophobic interaction; Neurite outgrowth-promoting peptide
资金
- Ministry of Education, Culture, Sports and Technology, Japan
Surface modification of poly(DL-lactic acid) (PLA) scaffolds has been performed using a biofunctional small peptide composed of collagen-like repetitive sequence and laminin-derived sequence (AG73-G(3)-(PPG)(5)) via hydrophobic interaction. The results of surface analysis suggest that AG73-G(3)-(PPG)(5) can be stably adsorbed onto PLA films via hydrophobic interaction at the (PPG)(5) region, and form an extracellular matrix-like layer composed of both structural and biosignalling sequences. In addition, neurite outgrowth of PC12 cells was observed on the AG73-G(3)-(PPG)(5)-adsorbed PLA film. These results indicate that AG73-G(3)-(PPG)(5) very effectively enhances neurite outgrowth activity on PLA films. The hydrophobic adsorption of collagen-like peptide bound to biosignalling molecules may be widely applied as a surface modifier of PLA films for tissue engineering. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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