期刊
ACTA BIOMATERIALIA
卷 6, 期 8, 页码 2932-2939出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2010.02.013
关键词
Biomimetics; Hydrogels; Calcium phosphates; Bone repair/regeneration; Stem cells
资金
- French National Research Agency (ANR TecSan)
To provide multipotent cells with a three-dimensional environment closer to bone matrix, an engineered construct mimicking bone components has been designed and evaluated A biocompatible hydrogel (silated hydroxypropylmethyl cellulose) was used as an extra-cellular matrix while biphasic calcium phosphate ceramic particles were used to replace mineralized matrix. Finally, human bone mesenchymal cells were cultured in three dimensions in the resulting constructs to study their cell viability, proliferation, interactions within the composites, and maintenance of their osteogenic potential This approach resulted in homogeneous structures in which cells were viable and retained their osteoblastic differentiation potential However, the cells did not proliferate nor colonize the constructs, possibly because of a lack of suitable interactions with their micro-environment (C) 2010 Acta Materialia Inc Published by Elsevier Ltd All rights reserved
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