期刊
ACTA BIOMATERIALIA
卷 5, 期 7, 页码 2570-2578出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2008.12.013
关键词
Wound dressing; Wound healing; EGF; Growth factors; Silk fibers
资金
- Center for Integrated Tissue Engineering at School of Dental Medicine at Tufts University
- NIH/NIBIB
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE017413] Funding Source: NIH RePORTER
Materials able to deliver topically bioactive molecules represent a new generation of biomaterials. In this article, we describe the use of silk mats, made of electrospun nanoscale silk fibers containing epidermal growth factor (EGF), for the promotion of wound healing processes. In our experiments, we demonstrated that EGF is incorporated into the silk mats and slowly released in a time-dependent manner (25% EGF release in 170 h). We tested these materials using a new model of wounded human skin-equivalents displaying the same structure as human skin and able to heal using the same molecular and cellular mechanisms found in vivo. This human three-dimensional model allows us to demonstrate that the biofunctionalized silk mats, when placed on the wounds as a dressing, aid the healing by increasing the time of wound closure by the epidermal tongue by 90%. The preservation of the structure of the mats during the healing period as demonstrated by electronic microscopy, the biological action of the dressing, as well as the biocompatibility of the silk demonstrate that this biomaterial is a new and very promising material for medical applications, especially for patients suffering from chronic wounds. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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