期刊
ACTA BIOMATERIALIA
卷 5, 期 6, 页码 2169-2177出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2009.02.007
关键词
Carbonate- and fluoride-substituted apatite (CFA); Crystallinity; Solubility
The mineral in bone is an impure hydroxyapatite, with carbonate as the chief minor substituent. Fluoride has been shown to stimulate osteoblastic activity and inhibit osteoclastic resorption in vitro. CO3- and F-substituted apatite (CFA) has been considered as potential bone graft material for orthopedic and dental applications. The objective of this study was to determine the effects of simultaneously incorporated CO3 and F on the crystallographic physico-chemical properties of apatite. The results showed that increasing CO3 and Na content in apatites with relatively constant F concentration caused a decrease in crystallite size and an increase in the extent of calcium release; increasing F content in apatites with relatively constant CO3 concentration caused an increase in crystallite size and a decrease in the extent of Ca release. These findings suggest that CFAs as bone graft materials of desired solubility can be prepared by manipulating the relative concentrations of CO3 and F incorporated in the apatite. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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