期刊
ACTA BIOMATERIALIA
卷 5, 期 1, 页码 328-337出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2008.07.030
关键词
Microspheres; PLGA; Scaffolds; Compressive properties; Chondrocytes
资金
- National High-tech Research and Development Program [2006AA03Z442]
- Major State Basic Research Program of China [2005CB623902]
- Science and Technology Program of Zhejiang Province [2006C13022]
- National Science Fund for Distinguished Young Scholars of China [50425311]
Poly(lactide-co-glycotide) (PLGA) microspheres integrated into gelatin/chitosan/hyaluronan scaffolds were fabricated by freeze-drying and crosslinking with 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide. The effects of the microspheres on porosity, density, compressive modulus, phosphate-buffered saline uptake ratio and weight loss of the scaffolds were evaluated. Generally, a scaffold with a higher PLGA content had a lower porosity and weight loss, and a medium uptake ratio, but a larger apparent density and compressive modulus. When the PLGA content was lower than 50%, the PLGA-integrated scaffolds had a similar pore size (similar to 200 mu m) as that of the control, and as much as 90% of their porosity could be preserved. In vitro chondrocyte culture in the 50% PLGA-integrated scaffold demonstrated that the cells could proliferate and secrete extracellular matrix at the same level as in the control gelatin/chitosan/hyaluronan scaffold. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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