Pt/TiO2 brain biocompatible nanoparticles: GBM treatment using the C6 model in Wistar rats

In the present work we synthesized inorganic oxide nanoparticle carriers of platinum compounds and tested their therapeutic effect on animal models in which C6 glioma cells have been inoculated. TiO2-containing Pt(NH3)(4)Cl-2 complexes were synthesized using sol-gel methods. The platinum species are chemically bonded to the TiO2 carrier, as shown by Fourier transform infrared spectroscopy of probe molecules. Treatment with TiO2-Pt nanoparticles reduces tumour growth rate by up to 56%, showing that a synergistic effect exists between the TiO2 carrier and the platinum drug. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.