期刊
ACTA BIOLOGICA HUNGARICA
卷 63, 期 -, 页码 80-88出版社
AKADEMIAI KIADO RT
DOI: 10.1556/ABiol.63.2012.Suppl.1.8
关键词
Hunger motivation; glucose-monitoring network; taste information processing; dopamine; reward
类别
资金
- NKTH-OTKA [K 68431]
- Ajinomoto Co. Inc. [51064/2009]
- Hungarian Academy of Sciences
- [SROP-4.2.2/B-10/1-2010-0029]
- [SROP-4.2.1/B-10/2/KONV-2010-0002]
While food intake and body weight are under homeostatic regulation, eating is a highly motivated and reinforced behavior that induces feelings of gratification and pleasure. The chemical senses (taste and odor) and their evaluation are essential to these functions. Brainstem and limbic glucose-monitoring (GM) neurons receiving neurochemical information from the periphery and from the local brain milieu are important controlling hunger motivation, and brain gut peptides have a modulatory role on this function. The hypothalamic and limbic forebrain areas are responsible for evaluation of reward quality and related emotions. They are innervated by the mesolimbic dopaminergic system (MLDS) and majority of GM neurons are also influenced by dopamine. Via dopamine release, the MLDS plays an essential role in rewarding-reinforcing processes of feeding and addiction. The GM network and the M LDS in the limbic system represent essential elements in the neural substrate of motivation.
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