期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 44, 期 4, 页码 281-299出版社
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmr118
关键词
human ribosome; photoaffinity cross-linking; mRNA and tRNA binding site; hepatitis C IRES binding site; ribosomal component
资金
- Russian Foundation for Basic Research [11-04-00597]
- Presidium of the Russian Academy of Sciences
This review covers data on the structural organization of functional sites in the human ribosome, namely, the messenger RNA binding center, the binding site of the hepatitis C virus RNA internal ribosome entry site, and the peptidyl transferase center. The data summarized here have been obtained primarily by means of a site-directed cross-linking approach with application of the analogs of the respective ribosomal ligands bearing cross-linkers at the designed positions. These data are discussed taking into consideration available structural data on ribosomes from various kingdoms obtained with the use of cryo-electron microscopy, X-ray crystallography, and other approaches.
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