期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 43, 期 10, 页码 745-756出版社
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmr079
关键词
Wnt5a; calcium signaling; development; cancer; inflammation; neurodegeneration
资金
- Saha Institute of Nuclear Physics, Government of India
The non-canonical Wnt/Ca2+ signaling cascade is less characterized than their canonical counterpart, the Wnt/beta-catenin pathway. The non-canonical Wnt signaling pathways are diverse, defined as planer cell polarity pathway, Wnt-RAP1 signaling pathway, Wnt-Ror2 signaling pathway, Wnt-PKA pathway, Wnt-GSK3MT pathway, Wnt-aPKC pathway, Wnt-RYK pathway, Wnt-mTOR pathway, and Wnt/calcium signaling pathway. All these pathways exhibit a considerable degree of overlap between them. The Wnt/Ca2+ signaling pathway was deciphered as a crucial mediator in development. However, now there is substantial evidence that the signaling cascade is involved in many other molecular phenomena. Many aspects of Wnt/Ca2+ pathway are yet enigmatic. This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca2+ signaling pathway.
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