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The X Protein of Hepatitis B Virus Inhibits Apoptosis in Hepatoma Cells through Enhancing the Methionine Adenosyltransferase 2A Gene Expression and Reducing S-Adenosylmethionine Production
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Hepatitis B Virus Protein X-induced Expression of the CXC Chemokine IP-10 Is Mediated through Activation of NF-κB and Increases Migration of Leukocytes
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Hepatitis B virus X protein upregulates HSP90alpha expression via activation of c-Myc in human hepatocarcinoma cell line, HepG2
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Stimulation of hepatitis B virus genome replication by HBx is linked to both nuclear and cytoplasmic HBx expression
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HBx protein induces expression of MIG and increases migration of leukocytes through activation of NF-κB
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VIROLOGY (2009)
Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice
Victor V. Keasler et al.
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Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication
Kai-Fu Tang et al.
BIOLOGICALS (2008)
Subcellular Mislocalization of Mutant Hepatitis B X Proteins Contributes to Modulation of STAT/SOCS Signaling in Hepatocellular Carcinoma
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Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria
Hye Jin Kim et al.
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Identification of functionally important amino acid residues in the mitochondria targeting sequence of Hepatitis B virus X protein
Sai Kam Li et al.
VIROLOGY (2008)
Hepatitis B virus replication is associated with an HBx-Dependent mitochondrion-regulated increase in cytosolic calcium levels
Stephanie L. McClain et al.
JOURNAL OF VIROLOGY (2007)
Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells
Naoki Oishi et al.
CANCER SCIENCE (2007)
Molecular functions and biological roles of hepatitis B virus x protein
Hong Tang et al.
CANCER SCIENCE (2006)
Negative regulation of hepatitis B virus replication by cellular Hsp40/DnaJ proteins through destabilization of viral core and X proteins
Sook-Young Sohn et al.
JOURNAL OF GENERAL VIROLOGY (2006)
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues
XD Zhang et al.
JOURNAL OF MEDICAL VIROLOGY (2005)
Hepatitis B virus X protein sensitizes UV-induced apoptosis by transcriptional transactivation of Fas ligand gene expression
SY Kim et al.
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Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERKs and PI-3K/AKT pathways: Involvement of invasive potential
TW Chung et al.
FASEB JOURNAL (2004)
Heal and colonic oxalate flux increases in a rat model of enteric hyperoxaluria and calcium oxalate stone pathogenesis
KA Kles et al.
FASEB JOURNAL (2004)
cDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesis
RK Ng et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
The enigmatic X gene of hepatitis B virus
MJ Bouchard et al.
JOURNAL OF VIROLOGY (2004)
Subcellular localization and transcriptional repressor activity of HBx on p21WAF1/Cip1 promoter is regulated by ERK-mediated phosphorylation
EJ Noh et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Activation of calcium signaling by hepatitis B virus-X protein in liver cells
JC Oh et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2003)
Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein
M Chami et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
HBXIP functions as a cofactor of survivin in apoptosis suppression
H Marusawa et al.
EMBO JOURNAL (2003)
Integrity of c-Raf-1/MEK signal transduction cascade is essential for hepatitis B virus gene expression
L Stöckl et al.
ONCOGENE (2003)
Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal
KH Kim et al.
EMBO JOURNAL (2003)
The Ras-Raf-MEK-ERK pathway in the treatment of cancer
RA Hilger et al.
ONKOLOGIE (2002)
The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver
O Terradillos et al.
ONCOGENE (2002)
DDB2 induces nuclear accumulation of the hepatitis B virus X protein independently of binding to DDB1
A Nag et al.
JOURNAL OF VIROLOGY (2001)
Hepatitis B virus X protein: a multifunctional viral regulator
S Murakami
JOURNAL OF GASTROENTEROLOGY (2001)
Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes
C Tarn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Interaction of the hepatitis B virus X protein with the Crm1-dependent nuclear export pathway
M Forgues et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis
JY Diao et al.
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The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade
YI Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Intracellular localization of the hepatitis B virus HBx protein
F Henkler et al.
JOURNAL OF GENERAL VIROLOGY (2001)
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway
JY Diao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4:: potential mechanism of hepatitis B virus-induced liver fibrosis
DK Lee et al.
GENES & DEVELOPMENT (2001)
Hepatitis B virus X protein inhibits transforming growth factor-β-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway
WL Shih et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Selective transcriptional regulations in the human liver cell by hepatitis B viral X protein
JS Han et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex
ZS Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential
Z Rahmani et al.
JOURNAL OF VIROLOGY (2000)