期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 41, 期 12, 页码 973-979出版社
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmp091
关键词
chemerin; proteolysis; chemotactic; inflammation
资金
- NIH [RO1 HL57530]
Chemerin is a novel chemoattractant recognized by chemokine-like receptor 1 (CMKLR1), a serpentine receptor expressed primarily by plasmacytoid dendritic cells, natural killer cells, and macrophages. Human prochemerin circulates in plasma as an inactive precursor. Its chemotactic activity is expressed upon cleavage of the C-terminal amino acid residues by proteases of the coagulation, fibrinolytic, and inflammatory system. The C-terminal cleavage site of prochemerin is highly conservative, indicating that the proteolytic regulation of chemerin bioactivity is a common mechanism undertaken by different species. In this review, we summarized chemerin-proteases interactions, chemerin receptors, and their importance in normal and pathologic conditions.
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