期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 41, 期 6, 页码 472-477出版社
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmp035
关键词
microRNA; diabetes; GK (Goto-Kakizaki) rat; Wistar rat; p38 MAPK
资金
- National Key Basic Research and Development Program [2005CB724602]
- Chinese Academy of Sciences [KSCX1-YW-R-64, KSCX2-YW-R-096]
MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function on type 2 diabetes, we used an oligonucleotide microarray to monitor miRNA expression profiles of Goto-Kakizaki (GK) and Wistar rats' skeletal muscle. It was found that seven miRNAs were down-expressed and two miRNAs were over-expressed in the muscle of GK rats. Among them, miR-24 showed the most prominent change. p38 MAPK, which is a direct target of miR-24, also showed expression difference. All the data give a clue that miR-24 might be associated with diabetes through down-regulation of p38 MAPK.
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