期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 42, 期 1, 页码 1-7出版社
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmp108
关键词
c-myb; CXCL12 promoter; transcription regulation
资金
- Shanghai Pujiang Program
- Natural Science Foundation of Shanghai [09ZR1406900]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars
- State Education Ministry and Innovation Program of Shanghai Municipal Education Commission [09ZZ04]
Chemokine C-X-C motif ligand 12 (CXCL12) is a potent chemotactic and angiogenic factor that has been proposed to play a role in organ-specific metastasis and angiogenic activity in several malignancies. In this study, we found that the overexpression of c-myb could elevate CXCL12 mRNA level and CXCL12 promoter activity in human T47D and MCF-7 breast cancer cells. Chromatin immunoprecipitation assay demonstrated that c-myb could bind to the CXCL12 promoter in the cells transfected with c-myb expression vector. c-myb siRNA attenuated CXCL12 promoter activity and the binding of c-myb to the CXCL12 promoter in T47D and MCF-7 cells. These results indicated that c-myb could activate CXCL12 promoter transcription.
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