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Xu Huang et al.
BIOCHEMICAL JOURNAL (2008)
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity
Shumin Zhang et al.
CANCER RESEARCH (2008)
STRAD alpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7
Julia Dorfman et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain
Purna Mukherjee et al.
MOLECULAR CANCER (2008)
Crossing the nuclear envelope: Hierarchical regulation of nucleocytoplasmic transport
Laura J. Terry et al.
SCIENCE (2007)
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
Ryan J. O. Dowling et al.
CANCER RESEARCH (2007)
High-level expression of functional tumor suppressor LKB1 in Escherichia coli
Jun'e Liu et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2007)
Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas
Esther Conde et al.
HUMAN PATHOLOGY (2007)
LKB1 modulates lung cancer differentiation and metastasis
Hongbin Ji et al.
NATURE (2007)
Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27Kip1 induction
Xiaoduo Xie et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2007)
Energy-dependent regulation of cell structure by AMP-activated protein kinase
Jun Hee Lee et al.
NATURE (2007)
LKB1 catalytically deficient mutants enhance cyclin D1 expression
Kristine D. Scott et al.
CANCER RESEARCH (2007)
LKB1 and AMPK maintain epithelial cell polarity under energetic stress
Vincent Mirouse et al.
JOURNAL OF CELL BIOLOGY (2007)
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
Anthony P. Barnes et al.
CELL (2007)
LKB1/STRAD promotes axon initiation during neuronal polarization
Maya Shelly et al.
CELL (2007)
Interference with energy metabolism by 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induces HPV suppression in cervical carcinoma cells and apoptosis in the absence of LKB1
Julia Nafz et al.
BIOCHEMICAL JOURNAL (2007)
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
Matthew J. Sanders et al.
BIOCHEMICAL JOURNAL (2007)
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo
Jonathan B. Hurov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer
J. Carretero et al.
ONCOGENE (2007)
The energy sensing LKB1-AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
Jiyong Liang et al.
NATURE CELL BIOLOGY (2007)
Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegans
Wesley Hung et al.
DEVELOPMENT (2007)
LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation
Ping-Yao Zeng et al.
CANCER RESEARCH (2006)
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves, glucose homeostasis, and decreases TRB3
Ho-Jin Koh et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
LKB1 mutation in large cell carcinoma of the lung
Diansheng Zhong et al.
LUNG CANCER (2006)
JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila
J. H. Lee et al.
CELL DEATH AND DIFFERENTIATION (2006)
LKB1 protein expression in human breast cancer
Hubert Fenton et al.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2006)
The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1
T Setogawa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Frequency and spectrum of cancers in the Peutz-Jeghers syndrome
Nicholas Hearle et al.
CLINICAL CANCER RESEARCH (2006)
A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma
W. Qiu et al.
ONCOGENE (2006)
Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo
J Bayraktar et al.
JOURNAL OF CELL SCIENCE (2006)
AMPK: A key sensor of fuel and energy status in skeletal muscle
DG Hardie et al.
PHYSIOLOGY (2006)
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
RJ Shaw et al.
SCIENCE (2005)
High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome
S Aretz et al.
HUMAN MUTATION (2005)
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
SH Koo et al.
NATURE (2005)
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
K Sakamoto et al.
EMBO JOURNAL (2005)
Mammalian SAD kinases are required for neuronal polarization
M Kishi et al.
SCIENCE (2005)
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
BB Kahn et al.
CELL METABOLISM (2005)
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
RJ Shaw et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton
D Cohen et al.
JOURNAL OF CELL BIOLOGY (2004)
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
JM Lizcano et al.
EMBO JOURNAL (2004)
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
AF Baas et al.
CELL (2004)
Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor
CC Milburn et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
MARKing tau for tangles and toxicity
G Drewes
TRENDS IN BIOCHEMICAL SCIENCES (2004)
Analysis of the LKB1-STRAD-MO25 complex
J Boudeau et al.
JOURNAL OF CELL SCIENCE (2004)
The LKB1 tumor suppressor negatively regulates mTOR signaling
RJ Shaw et al.
CANCER CELL (2004)
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
MN Corradetti et al.
GENES & DEVELOPMENT (2004)
The polarity-inducing kinase Par-1 controls Xenopus gastrulation in cooperation with 14-3-3 and aPKC
M Kusakabe et al.
EMBO JOURNAL (2004)
Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene
J Carretero et al.
ONCOGENE (2004)
Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells
R Benton et al.
CELL (2003)
MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
J Boudeau et al.
EMBO JOURNAL (2003)
In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila
JH Lee et al.
FEBS LETTERS (2003)
LKB1, a protein kinase regulating cell proliferation and polarity
J Boudeau et al.
FEBS LETTERS (2003)
Management of cellular energy by the AMP-activated protein kinase system
DG Hardie et al.
FEBS LETTERS (2003)
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
AF Baas et al.
EMBO JOURNAL (2003)
The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl
J Betschinger et al.
NATURE (2003)
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity
SG Martin et al.
NATURE (2003)
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
N Bardeesy et al.
NATURE (2002)
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
DR Bolster et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
LKB1 - A master tumour suppressor of the small intestine and beyond
LI Yoo et al.
NATURE REVIEWS CANCER (2002)
Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis
K Jishage et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Growth arrest by the LKB1 tumor suppressor:: induction of p21WAF1/CIP1
M Tiainen et al.
HUMAN MOLECULAR GENETICS (2002)
Epithelial-mesenchymal transitions in tumour progression
JP Thiery
NATURE REVIEWS CANCER (2002)
Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate
JW Scott et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Identification and characterization of four novel phosphorylation sites (Ser(31), Ser(325), Thr(336) and Thr(366)) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome
GP Sapkota et al.
BIOCHEMICAL JOURNAL (2002)
LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest
PA Marignani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent protein kinase, but not its farnesylation at Cys433, is essential for LKB1 to suppress cell growth
GP Sapkota et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
P Karuman et al.
MOLECULAR CELL (2001)
5′-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer
J Trojan et al.
GUT (2000)
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome
M Esteller et al.
ONCOGENE (2000)
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