期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 40, 期 7, 页码 554-564出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1745-7270.2008.00439.x
关键词
Kruppel-like factor 4; colorectal cancer; stem cell
资金
- NCI NIH HHS [T32 CA117834, T32 CA117834-02, T32CA117834] Funding Source: Medline
Kruppel-like factor 4 (KLF4) is a zinc finger-type transcription factor expressed in a variety of tissues, including the epithelium of the intestine and the skin, and it plays an important role in differentiation and cell cycle arrest. Depending on the gene targeted, KLF4 can both activate and repress transcription. Moreover, in certain cellular contexts, KLF4 can function as a tumor suppressor or an oncogene. Finally, KLF4 is important in reprogramming differentiated fibroblasts into inducible pluripotent stem cells, which highly resemble embryonic stem cells. This review summarizes what is known about the diverse functions of KLF4 as well as their molecular mechanisms.
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