期刊
JOURNAL OF FUNCTIONAL BIOMATERIALS
卷 2, 期 2, 页码 67-87出版社
MDPI
DOI: 10.3390/jfb2020067
关键词
ESCs; ASCs; iPS; mechanotransduction; regenerative medicine; tissue engineering
资金
- Italian Fondazione Cassa di Risparmio di Perugia [2009.020.0050, 2010,0110445]
- Italian Ministero dell'Istruzione, dell'Universita e della Ricerca [20084XRSBS_001]
- Istituto Nazionale Biostrutture e Biosistemi
It is a general concern that the success of regenerative medicine-based applications is based on the ability to recapitulate the molecular events that allow stem cells to repair the damaged tissue/organ. To this end biomaterials are designed to display properties that, in a precise and physiological-like fashion, could drive stem cell fate both in vitro and in vivo. The rationale is that stem cells are highly sensitive to forces and that they may convert mechanical stimuli into a chemical response. In this review, we describe novelties on stem cells and biomaterials interactions with more focus on the implication of the mechanical stimulation named mechanotransduction.
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