期刊
CURRENT COLORECTAL CANCER REPORTS
卷 7, 期 2, 页码 113-120出版社
SPRINGER
DOI: 10.1007/s11888-011-0086-1
关键词
RAS signaling pathway; Oncogene; Colorectal cancer; KRAS and B-RAF mutations; Mouse models
类别
资金
- National Institutes of Health [DK52230, DK64399, CA84197]
Deaths caused by colorectal cancer (CRC) are among the leading causes of cancer-related death in the United States and around the world. Approximately 150,000 Americans are diagnosed with CRC each year and around 50,000 will die from it. Mutations in many key genes have been identified that are important to the pathogenesis of CRC. Among the genes mutated in CRC, RAS and RAF mutations are common events. Both RAS and RAF are critical mediators of the mitogen-activated protein kinase (MAPK) pathway that is involved in regulating cellular homeostasis, including proliferation, survival, and differentiation. In this review, we provide a historical perspective and update on RAS/RAF mutations as related to colorectal cancer. Additionally, we will review recent mouse models of RAS and RAF mutations that have an impact on CRC research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据