期刊
ACS NANO
卷 12, 期 10, 页码 10201-10211出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b05200
关键词
erythrocyte membrane; metal-organic framework; glucose oxidase; biomimetic nanoreactor; starvation-activated therapy
类别
资金
- National Natural Science Foundation of China [21871249, 21820102009, 21533008, 21673223, 21431007, 21601175]
- Jilin Province Science and Technology Development Plan Project [20160520129JH, 20170101184JC]
- Key Program of Frontier of Sciences [CAS QYZDJ-SSW-SLH052]
Shutting down glucose supply by glucose oxidase (GOx) to starve tumors has been considered to be an attractive strategy in cancerous starvation therapy. Nevertheless, the in vivo applications of GOx-based starvation therapy are severely restricted by the poor GOx delivery efficiency and the self-limiting therapeutic effect. Herein, a biomimetic nanoreactor has been fabricated for starvation-activated cancer therapy by encapsulating GOx and prodrug tirapazamine (TPZ) in an erythrocyte membrane cloaked metal-organic framework (MOF) nanoparticle (TGZ@eM). The fabricated TGZ@eM nanoreactor can assist the delivery of GOx to tumor cells and then exhaust endogenous glucose and O-2 to starve tumors efficiently. Importantly, the resulting tumor hypoxia by GOx-based starvation therapy further initiates the activation of TPZ, which is released from the nanoreactor in the acid lyso/endosome environment, for enhanced colon cancer therapy. More importantly, by integrating the biomimetic surface modification, the immunity-escaping and prolonged blood circulation characteristics endow our nanoreactor dramatically improved cancer targeting ability. The in vitro and in vivo outcomes indicate our biomimetic nanoreactor exhibits a strong synergistic cascade effect for colon cancer therapy in an accurate and facile manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据