期刊
ACS NANO
卷 12, 期 9, 页码 9532-9540出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b05090
关键词
three-photon excited fluorescence microscopy; perylene diimide; aggregation-induced emission; isolation group; deep-red emission
类别
资金
- National Natural Science Foundation of China [51673151, 51573140, 21734007]
- Hubei Province [2017CFA002]
- Fundamental Research Funds for the Central Universities [204201710247, 2042018kf0014]
- Zhejiang Provincial Natural Science Foundation of China [LR17F050001]
The development of fluorogens with deep-red emission is one of the hottest topics of investigation in the field of bio/chemosensors and bioimaging. Herein, the tunable fluorescence of perylene diimide (PDI) derivatives was achieved by the incorporation of varied isolation groups linked on the PDI core. With the enlarged sizes of isolation groups, the conversion from aggregation caused quenching to aggregation-induced emission was obtained in their fluorescence variations from solutions to nanoparticles, as the result of the efficient inhibition of pi-pi stacking by the larger isolation groups. Accordingly, DCzPDI bearing 1,3-di(9H-carbazol-9-yl)benzene as the biggest isolation group exhibited the bright deep-red emission in the aggregated state with a quantum yield of 12.3%. Combined with the three-photon excited fluorescence microscopy (3PFM) technology, through-skull 3PFM imaging of mouse cerebral vasculature can be realized by DCzPDI nanoparticles with good biocompatibility, and the penetration depth can be as deep as 450 mu m.
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