Isotretinoin effect on alveolar repair after exodontia-a study in rats

Objectives To evaluate isotretinoin effect on alveolar repair after tooth extraction of maxillary incisor and serum calcium levels in rats. Study design Wistar rats (60-day-old) were assigned to control (CG, n=12) and experimental (EG, n=20) groups. EG received daily isotretinoin (7.5 mg/kg) for 30 days before surgery and until euthanasia, 7, 21, 28, or 90 days after tooth extraction. Blood was collected in the EG to analyze serum calcium levels before isotretinoin adminis-tration and at euthanasia. Right hemimaxillae underwent histological examination, and the slides were stained with HE and analyzed by descriptive light microscopy. Results There was acceleration in the process of alveolar repair in the EG at all time points when compared to controls. Serum calcium levels showed a statistically significant decrease between first and second blood collection at days 21, 28, and 90. Conclusions Daily isotretinoin in a dose corresponding to the treatment of cystic acne accelerated alveolar repair.