期刊
ACS NANO
卷 8, 期 5, 页码 4348-4357出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn406019m
关键词
hydrogel; polymer; biomaterial; electronically active
类别
资金
- Shurl and Kay Curci Foundation
- Berkman Foundation
- American Chemical Society Petroleum Research Fund (ACS PRF) [51980-DNI7]
- National Science Foundation [DMR 09-69301]
- National Institutes of Health (NIH) [R21EB015165]
- U.S. Army Materiel Command [W81XWH1210626]
- National Natural Science Foundation of China [NSFC51273022]
- Molecular Biosensor & Imaging Center in Carnegie Mellon University
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [969301] Funding Source: National Science Foundation
The emergence of flexible and stretchable electronic components expands the range of applications of electronic devices. Flexible devices are ideally suited for electronic biointerfaces because of mechanically permissive structures that conform to curvilinear structures found in native tissue. Most electronic materials used in these applications exhibit elastic moduli on the order of 0.1-1 MPa. However, many electronically excitable tissues exhibit elasticities in the range of 1-10 kPa, several orders of magnitude smaller than existing components used in flexible devices. This work describes the use of biologically derived heparins as scaffold materials for fabricating networks with hybrid electronic/ionic conductivity and ultracompliant mechanical properties. Photo-cross-linkable heparin methacrylate hydrogels serve as templates to control the microstructure and doping of in situ polymerized polyaniline structures. Macroscopic heparin-doped polyaniline hydrogel dual networks exhibit impedances as low as Z = 4.17 Omega at 1 kHz and storage moduli of G' = 900 +/- 100 Pa. The conductivity of heparin/polyaniline networks depends on the oxidation state and microstructure of secondary polyaniline networks. Furthermore, heparin/polyaniline networks support the attachment, proliferation, and differentiation of mu rifle myoblasts without any surface treatments. Taken together, these results suggest that heparin/polyaniline hydrogel networks exhibit suitable physical properties as an electronically active biointerface material that can match the mechanical properties of soft tissues composed of excitable cells.
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