期刊
ACS NANO
卷 8, 期 8, 页码 7746-7754出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn5029955
关键词
nanomotor; magnetic nanorods; stroke; acceleration of thrombolysis; enhanced mass transport
类别
资金
- National Science Foundation [ECCS-09011, ECCS-1303134, ECCS-1150042]
- National Institutes of Health [R21 NS084148-01A1]
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [1150042, 1303134] Funding Source: National Science Foundation
Dose control and effectiveness promotion of tissue plasminogen activator (t-PA) for thrombolysis are vitally important to alleviate serious side effects such as hemorrhage in stroke treatments. In order to increase the effectiveness and reduce the risk of stroke treatment, we use rotating magnetic nanomotors to enhance the mass transport of t-PA molecules at the blood clot interface for local ischemic stroke therapy. The in vitro experiments demonstrate that, when combined with magnetically activated nanomotors, the thrombolysis speed of low-concentration t-PA (50 mu g mL(-1)) can be enhanced up to 2-fold, to the maximum lysis speed at high t-PA concentration. Based on the convection enhanced transport theory due to rotating magnetic nanomotors, a theoretical model is proposed and predicts the experimental results reasonably well. The validity and efficiency of this enhanced treatment has been demonstrated in a rat embolic model.
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