期刊
ACS NANO
卷 8, 期 6, 页码 6004-6013出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn501134q
关键词
photodynamic therapy; EPR; ferritin; nanoparticles; drug delivery; integrin alpha(v)beta(3)
类别
资金
- NCI/NIH [5R00CA153772]
- Intramural Research Program of NIBIB, NIH
- National Science Foundation [CAREER DMR-0955908]
- NIH [R01HL093339, RR005351/GM103390]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0955908] Funding Source: National Science Foundation
Delivery of nanoparticle drugs to tumors relies heavily on the enhanced permeability and retention ((PR) effect. While many consider the effect to be equally effective on all tumors, it varies drastically among the tumors' origins, stages, and organs, owing much to differences in vessel leakiness. Suboptimal (PR effect represents a major problem in the translation of nanomedicine to the clinic. In the present study, we introduce a photodynamic therapy (PDT)-based (PR enhancement technology. The method uses RGD-modified ferritin (RFRT) as smart carriers that site-specifically deliver O-1(2) to the tumor endothelium. The photodynamic stimulus can cause permeabilized tumor vessels that facilitate extravasation of nanoparticles at the sites. The method has proven to be safe, selective, and effective. Increased tumor uptake was observed with a wide range of nanoparticles by as much as 20.08-fold. It is expected that the methodology can find wide applications in the area of nanomedicine.
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