期刊
ACS NANO
卷 9, 期 1, 页码 251-259出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn504508s
关键词
RNA and DNA nanotechnology; RNA and DNA nanoparticles; RNAi; FRET; RNA-DNA hybrids reassociation
类别
资金
- Frederick National Laboratory for Cancer Research, National Institutes of Health [HHSN261200800001E]
- Intramural Research Program of the National Institutes of Health, Center for Cancer Research
Control over cellular delivery of different functionalities and their synchronized activation is a challenging task. We report several RNA and RNA/DNA-based nanoparticles designed to conditionally activate the RNA interference in various human cells. These nanoparticles allow precise control over their formulation, stability in blood serum, and activation of multiple functionalities. Importantly, interferon and pro-inflammatory cytokine activation assays indicate the significantly lower responses for DNA nanoparticles compared to the RNA counterparts, suggesting greater potential of these molecules for therapeutic use.
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