期刊
ACS NANO
卷 8, 期 10, 页码 10621-10630出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn505051d
关键词
upconverting; nanoparticles; red-emission; prodrug; photodynamic therapy
类别
资金
- University of Massachusetts Medical School, UMass CVIP Technology Development Award
- National Institute of Health [R01MH103133]
- Human Frontier Science Program
- Office of Science, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering, of the U.S. Department of Energy [DE-AC02-05CH11231]
A class of biocompatible upconverting nanoparticles (UCNPs) with largely amplified red-emissions was developed. The optimal UCNP shows a high absolute upconversion quantum yield of 3.2% in red-emission, which is 15-fold stronger than the known optimal beta-phase core/shell UCNPs. When conjugated to aminolevulinic acid, a clinically used photodynamic therapy (PDT) prodrug, significant PDT effect in tumor was demonstrated in a deep-tissue (>1.2 cm) setting in vivo at a biocompatible laser power density. Furthermore, we show that our UCNP-PDT system with NIR irradiation outperforms clinically used red light irradiation in a deep tumor setting in vivo. This study marks a major step forward in photodynamic therapy utilizing UCNPs to effectively access deep-set tumors. It also provides an opportunity for the wide application of upconverting red radiation in photonics and biophotonics.
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