期刊
ACS NANO
卷 8, 期 6, 页码 6123-6130出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn5014808
关键词
boron nitride; water-soluble; porous; drug delivery; cytotoxicity
类别
资金
- World Premier International Center for Materials Nanoarchitectonics (WPI-MANA) of NIMS, Tsukuba, Japan
Developing materials for Nano-vehicles with clinically approved drugs encapsulated is envisaged to enhance drug therapeutic effects and reduce the adverse effects. However, design and preparation of the biomaterials that are porous, nontoxic, soluble, and stable in physiological solutions and could be easily functionalized for effective drug deliveries are still challenging. Here, we report an original and simple thermal substitution method to fabricate perfectly water-soluble and porous boron nitride (BN) materials featuring unprecedentedly high hydroxylation degrees. These hydroxylated BNs are biocompatible and can effectively load anticancer drugs (e.g., doxorubicin, DOX) up to contents three times exceeding their own weight. The same or even fewer drugs that are loaded on such BN carriers exhibit much higher potency for reducing the viability of LNCaP cancer cells than free drugs.
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