期刊
ACS NANO
卷 8, 期 8, 页码 7870-7879出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn5027214
关键词
mesoporous silica; mesoporous carbon; core-shell; targeted delivery; combined therapy
类别
资金
- National Key Basic Research Program of China (973 Program) [2013CB932502]
- National Natural Science Foundation of China [21303022]
- Zhuo Xue Talent Plan of Fudan University
- Natural Science Foundation of Shanghai City of China [13ZR1451400]
- Sino-German Research Project [GZ995]
- Fudan University Key Laboratory Senior Visiting Scholarship
Tumor site-directed multifunctional therapeutic platforms such as photothermochemotherapy that respond to tumor focused physical and biological stimuli are highly demanded for effective cancer therapy. Herein, targeting peptide-conjugated core shell graphitic carbon@silica nanospheres with dual-ordered mesopores (MMPS) were successfully fabricated and developed as antitumoral doxorubicin (DOX) delivery system (MMPSD) for synergistic targeted photothermal chemotherapy of breast cancer. The hydrophilic rnesoporous silica shell guarantees good water dispersity of MMPSD. The hydrophobic graphitic mesoporous carbon core provides excellent hydrophobic drug loading, immediate contact between the drug and photothermal hotspots, and high NIR photothermal conversion efficiency. SP13 peptide facilitates MMPSD for targeted and enhanced delivery of DOX within HER2-positive SK-BR-3 breast cancer cells, while PEGylation ensures biocompatibility. Thus, the MMPSD system exhibited efficient drug loading capacity, high targeting ability, sensitive NIR/pH-responsive DOX release, sustained release, and excellent combined antitumor activity.
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