期刊
ACS NANO
卷 8, 期 11, 页码 11042-11052出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn503960h
关键词
peptide assembly; delivery systems; protein misfolding; cell penetration; neurodegeneration
类别
资金
- State of Thuringia
- Federal Government of Germany
- DFG [SFB 610]
- country Sachsen-Anhalt (Exzellenznetzwerk Biowissenschaften)
- BMBF (BioFuture)
Amyloid oligomers are nonfibrillar polypeptide aggregates linked to diseases, such as Alzheimers and Parkinsons. Here we show that these aggregates possess a compact, quasi-crystalline architecture that presents significant nanoscale regularity. The amyloid oligomers are dynamic assemblies and are able to release their individual subunits. The small oligomeric size and spheroid shape confer diffusible characteristics, electrophoretic mobility, and the ability to enter hydrated gel matrices or cells. We finally showed that the amyloid oligomers can be labeled with both fluorescence agents and iron oxide nanoparticles and can target macrophage cells. Oligomer amyloids may provide a new biological nanomaterial for improved targeting, drug release, and medical imaging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据