期刊
ACS NANO
卷 8, 期 10, 页码 10125-10138出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn502923s
关键词
electromagnetic fields; cell reprogamming; epigenetic changes
类别
资金
- National Research Foundation of Korea - Ministry of Education, Science, and Technology [NRF-2009-0082941, NRF-2013R1A1A1058835, NRF-2013M3A9B4076485, NRF-2013M3A9B4044387]
- Korea Health Technology R&D Project, Ministry of Health Welfare [HI13C0540]
- Next-Generation BioGreen 21 Program, Rural Development Administration [PJ009073]
Life on Earth is constantly exposed to natural electromagnetic fields (EMFs), and it is generally accepted that EMFs may exert a variety of effects on biological systems. Particularly, extremely low-frequency electromagnetic fields (EL-EMFs) affect biological processes such as cell development and differentiation; however, the fundamental mechanisms by which EMFs influence these processes remain unclear. Here we show that EMF exposure induces epigenetic changes that promote efficient somatic cell reprogramming to pluripotency. These epigenetic changes resulted from EMF-induced activation of the histone lysine methyltransferase Mll2. Remarkably, an EMF-free system that eliminates Earth's naturally occurring magnetic field abrogates these epigenetic changes, resulting in a failure to undergo reprogramming. Therefore, our results reveal that EMF directly regulates dynamic epigenetic changes through Mll2, providing an efficient tool for epigenetic reprogramming including the acquisition of pluripotency.
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