期刊
ACS NANO
卷 7, 期 2, 页码 1609-1617出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn305462y
关键词
silicon; nanoparticle; dynamic nuclear polarization; hyperpolarization; nanomedicine; magnetic resonance imaging
类别
资金
- DOE [DESC0002289]
- NIH [1 R21 EB007486-01A1]
- NSF BISH Program [CBET-0933015]
- Harvard NSF Nanoscale Science and Engineering Center
We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na4Si4) and silicon tetrachloride (SiCl4) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter similar to 10 nm with long size-adjusted Si-29 spin-lattice relaxation (T-1) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.
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