Field Effect Biosensing Platform Based on 2D α-MoO3

Electrical-based biosensing platforms offer ease of fabrication and simple sensing solutions. Recently, two-dimensional (2D) semiconductors have been proven to be excellent for the fabrication of field effect transistors (FETs) due to their large transconductance, which can be efficiently used for developing sensitive bioplatforms. We present a 2D molybdenum trioxide (MoO3) FIT based biosensing platform, using bovine serum albumin as a model protein. The conduction channel is a nanostructured film made of 2D alpha-MoO3 nanoflakes, with the majority of nanoflake thicknesses being equal to or less than 2.8 nm. The response time is impressively low (less than 10 s), which is due to the high permittivity of the 2D alpha-MoO3 nanoflakes. The system offers a competitive solution for future biosensing applications.