期刊
ACS NANO
卷 7, 期 11, 页码 10211-10217出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn4044854
关键词
DNA-based nanodevices; strand displacement; four-way junction; logic circuit; G-quadruplex
类别
资金
- National Natural Science Foundation of China [21075116, 21190040]
- 973 projects [2010CB933600, 2011CB911000]
We introduced a four-way DNA junction-driven toehold-mediated strand displacement method. Separation of the different functional domains on different strands in the four-way junction structure and usage of glue strand to recombine them for different logic gates make the design more flexible. On the basis of this mechanism, a majority logic circuit fabricated by DNA strands was designed and constructed by assembling three AND gates and one OR gate together. The output strand drew the G-rich segments together to form a split G-guadruplex, which could specifically bind PPIX and enhance its fluorescence. Just like a poll with three voters, the high fluorescence signal would be given off only when two or three voters vote in favor. Upon slight modification, the majority circuit was utilized to select the composite number from 0 to 9 represented by excess-three code. It is a successful attempt to integrate the logic gates into a circuit and to achieve desired functions.
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