期刊
ACS NANO
卷 7, 期 3, 页码 2012-2019出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn303998k
关键词
microtubule; microtubule-associated proteins; dynamic assembly; aster; microtubule organizing center; nanocrystals; quantum dot
类别
资金
- U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering
- U.S. Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000]
Microtubules (MTs) and the MT-associated proteins (MAPs) are critical cooperative agents Involved In complex nanoassembly processes In biological systems. These biological materials and processes serve as important Inspiration in developing new strategies for the assembly of synthetic nanomaterials In emerging tewhologies. Here, we explore a dynamic biofabrication process, modeled after the form and function of natural aster-like MT assemblies such as centrosomes. Specifically, we exploit the cooperative assembly of MTs and MAPs to form artificial microtubule asters and demonstrate that (1) these three-dimensional biomimetic microtubule asters can be controllably, reversibly assembled and (2) they serve as unique, dynamic biotemplates for the organization of secondary nanomaterials. We describe the MAP-mediated assembly and growth of functionalized MTs onto synthetic particles, the dynamic character of the assembled asters, and the application of these structures as templates for three-dimensional nanocrystal organization across multiple length scales. This biomediated nanomaterials assembly strategy illuminates a promising new pathway toward next-generation nanocomposite development
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据