期刊
ACS NANO
卷 7, 期 11, 页码 10066-10074出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn404166q
关键词
protein corona; nanorods; nanobones; carbon nanotubes; controlled release DNA
类别
资金
- NSF (DMR) [0906838]
- MIT-MISTI Spain Program
- IQS Fellowship
- La Caixa Fellowship
- NUS Fellowship
- Ministerio de Ciencia y Competividad of Spain [SAF2012-39947-C02-0]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0906838] Funding Source: National Science Foundation
We manipulate the passive release rates of DNA payloads on protein coronas formed around nanoparticles (NPs) by varying the corona composition. The coronas are prepared using a mixture of hard and soft corona proteins. We form coronas around gold nanorods (NRs), nanobones (NBs), and carbon nanotubes (CNTs) from human serum (HS) and find that tuning the amount of human serum albumin (HSA) in the NR-coronas (NR-HS-DNA) changes the payload release profile. The effect of buffer strength, HS concentration, and concentration of the cetyltrimethylammonium bromide (CTAB) passivating the NP surfaces on passive release is explored. We find that corona properties play an important role in passive release, and concentrations of CTAB, HS, and phosphate buffer used in corona formation can tune payload release profiles. These advances in understanding protein corona properties bring us closer toward developing a set of basic design rules that enable their manipulation and optimization for particular biological applications.
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