期刊
ACS NANO
卷 7, 期 7, 页码 5842-5849出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn400928z
关键词
magnetic resonance imaging; dark field microscopy; iron oxide nanoparticle; gold nanoparticle; copper
类别
资金
- MRSEC Program of the National Science Foundation [DMR-0819885]
- NCRR [P41 RR008079]
- NIBIB of the National Institutes of Health [P41 EB015894]
- W. M. Keck Foundation
- NSF through the MRSEC
- ERC
- MRI programs
- NIH CBITG [GM 08700]
We present the design and synthesis of a responsive magnetoplasmonic assembly for copper(I) which allows monitoring of the concentration of the metal both in three dimensions by magnetic resonance imaging and with high spatial resolution by dark field microscopy. The probe consists of azide-functionalized iron oxide nanoparticles 11.6 nm in diameter and acetylene-terminated gold nanoparticles 44 nm in diameter that form three-dimensional networks of intermingled magnetic and plasmonic nanoparticles in the presence of copper. This aggregation results in a decrease in longitudinal relaxivity, and an initial increase followed by a sharp decrease in transverse relaxivity, a change observable both by T-1- and T-2-weighted images, concomitantly with a decrease of surface plasmon resonance Intensity.
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