期刊
ACS NANO
卷 6, 期 4, 页码 2960-2968出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn204123p
关键词
cucurbituril; hyaluronic acid; hydrogels; supramolecular chemistry; tissue engineering
类别
资金
- Acceleration Research, Brain Korea 21, World Class University [R31-2008-000-10059-0, R33-2008-000-10054-0]
- Converging Research Center of National Research Foundation of Korea [2009-0081871]
- Ministry of Education, Science and Technology
- Ministry of Education, Science & Technology (MoST), Republic of Korea [R33-2008-000-10054-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2009-0081871] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A facile In situ supramolecular assembly and modular modification of biocompatible hydrogels were demonstrated using cucurbit[6]uril-conjugated hyaluronic add (CB[6]-HA), diaminohexane-conjugated HA (DAH-HA), and tags-CB[6] for cellular engineering applications. The strong and selective host-guest interaction between (KM and DAH made possible the supramolecular assembly of CB[6]/DAH-HA hydrogels In the presence of cells. Then, the 3D environment of CB[6]/DAH-HA hydrogels was modularly modified by the simple treatment with various multifunctional tags-CB[6]. Furthermore, we could confirm in situ formation of CB[6]/DAH-HA hydrogels under the skin of nude mice by sequential subcutaneous injections of CB[6]-HA and DAH-HA solutions. The fluorescence of modularly modified fluorescein isothiocyanate (FITC)-CB[6] In the hydrogels was maintained for up toll days, reflecting the feasibility to deliver the proper cues for cellular proliferation and differentiation In the body. Taken together, CB[6]/DAH-HA hydrogels might be successfully exploited as a 3D artificial extracellular matrix for various tissue engineering applications.
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