期刊
ACS NANO
卷 7, 期 1, 页码 566-575出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn304719q
关键词
cancer; circulating tumor cell; nanotopography; biomaterials; microfabrication
类别
资金
- National Science Foundation [ECCS 1231826]
- UM-SJTU Collaboration on Biomedical Technologies
- UM Comprehensive Cancer Center Prostate SPORE Pilot Project [NIH/NCI 5 P50 CA069568-15]
- Michigan Institute for Clinical & Health Research (MICHR) [2 UL1 TR000433-06]
- department of Mechanical Engineering of the University of Michigan
- Avon Foundation
- Breast Cancer Research Foundation
- National Institutes of Health
- National Science Foundation
- Directorate For Engineering [1231826] Funding Source: National Science Foundation
- Div Of Electrical, Commun & Cyber Sys [1231826] Funding Source: National Science Foundation
Circulating tumor cells (CTCs) detached from both primary and metastatic lesions represent a potential alternative to invasive biopsies as a source of tumor tissue for the detection, characterization and monitoring of cancers. Here we report a simple yet effective strategy for capturing CTCs without using capture antibodies. Our method uniquely utilized the differential adhesion preference of cancer cells to nanorough surfaces when compared to normal blood cells and thus did not depend on their physical size or surface protein expression, a significant advantage as compared to other existing CTC capture techniques.
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