期刊
ACS NANO
卷 6, 期 8, 页码 6767-6775出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn3014917
关键词
nanopore; nanofluidic transistor; DNA capture; gate manipulation; biomolecular switch
类别
资金
- National Institutes of Health [NIH P01 HG0000205]
- Defense Advanced Research Projects Agency [DARPA-N66001-09-1-2132]
- Natural Sciences and Engineering Research Council of Canada
We report the use of an array of electrically gated similar to 200 nm solid-state pores as nanofluidic transistors to manipulate the capture and passage of DNA. The devices are capable of reversibly altering the rate of DNA capture by over 3 orders of magnitude using sub-1 V biasing of a gate electrode. This efficient gating originates from the counter-balance of electrophoresis and electroosmosis, as revealed by quantitative numerical simulations. Such a reversible electronically tunable biomolecular switch may be used to manipulate nucleic acid delivery in a fluidic circuit, and its development is an important first step toward active control of DNA motion through solid-state nanopores for sensing applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据