期刊
ACS NANO
卷 6, 期 2, 页码 1065-1073出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn2045246
关键词
plasmonic shell-magnetic core nanoparticle; cancer cell isolation; targeted cancer imaging; photothermal destruction
类别
资金
- NSF-PREM [DMR-0611539]
- NIH-RCMI [5G12RR013459]
- NIH-MARC [5-T34-GM007672-28]
- Direct For Education and Human Resources
- Division Of Human Resource Development [833178] Funding Source: National Science Foundation
Cancer is the greatest challenge in human healthcare today. Cancer causes 7.6 million deaths and economic losses of around 1 trillion dollars every year. Early diagnosis and effective treatment of cancer are crucial for saving lives. Driven by these needs, we report the development of a multifunctional plasmonic shell-magnetic core nanotechnology-driven approach for the targeted diagnosis, isolation, and photothermal destruction of cancer cells. Experimental data show that aptamer-conjugated plasmonic/magnetic nanoparticles can be used for targeted imaging and magnetic separation of a particular kind of cell from a mixture of different cancer cells. A targeted photothermal experiment using 670 nm light at 2.5 W/cm(2) for 10 min resulted selective irreparable cellular damage to most of the cancer cells. We also showed that the aptamer-conjugated magnetic/plasmonic nanoparticle-based photothermal destruction of cancer cells is highly selective. We discuss the possible mechanism and operating principle for the targeted imaging, separation, and photothermal destruction using magnetic/plasmonic nanotechnology.
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