期刊
ACS NANO
卷 6, 期 4, 页码 2969-2977出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn2042362
关键词
near-infrared; photoluminescence; nanocrystals; lanthanide; bioimaging
类别
资金
- National Institutes of Health [R01CA119358, RO1CA104492]
- Swedish Energy Agency [32076-1]
- John R. Oishei Foundation
We have synthesized core/shell NaGdF4:Nd3(+)/NaGdF4 nanocrystals with an average size of 15 nm and exceptionally high photoluminescence (PL) quantum yield. When excited at 740 nm, the nanocrystals manifest spectrally distinguished, near-infrared to near-infrared (NIR-to-NIR) downconversion PL peaked at similar to 900, similar to 1050, and similar to 1300 nm. The absolute quantum yield of NIR-to-NIR PL readied 40% for core-shell nanoparticles dispersed in hexane. Time-resolved PL measurements revealed that this high quantum yield was achieved through suppression of nonradiative recombination originating from surface states and cross relaxations between dopants. NaGdF4:Nd3+/NaGdF4 nanocrystals, synthesized in organic media, were further converted to be water-dispersible by eliminating the capping ligand of oleic add. NIR-to-NIR PL bioimaging was demonstrated both in 14110 and in vivo through visualization of the NIR-to-NIR PL at 900 nm under Incoherent lamp light excitation. The fact that both excitation and the PL of these nanocrystals are in the biological window of optical transparency, combined with their high quantum efficiency, spectral sharpness, and photostability, makes these nanocrystals extremely promising as optical biomaging probes.
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