期刊
ACS NANO
卷 6, 期 2, 页码 1619-1624出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn204591r
关键词
MRI; contrast agent; relaxivity; nanocrystal; SPIO; cluster
类别
资金
- European Union [FP7-228933-2]
Concerning the outer sphere relaxation theory, the sensitivity of a T-2 MRI contrast agent, expressed by the transverse relaxivity r(2), depends on the diffusion length of water molecules relative to the particle size. For T-2-weighted spin-echo imaging, theoretical concepts reveal three regimes regarding the r(2) relaxivity depending on the nanocrystal size: the motional averaging regime (MAR), the static dephasing regime (SDR), and the echo-limiting regime (ELR). The r(2) maximum corresponds to the SDR, which represents a small size regime. To verify the theoretical concepts and to adjust the SDR, tailor-made T-2 contrast agents were synthesized by controlled self-assembly of superparamagnetic iron oxide nanocrystals (SPIOs) into raspberry-like nanoclusters with diameters of 30-200 nm using a PEG-based ligand. The results highlight an opportunity to optimize the relaxivity of T-2 contrast agents by tuning the cluster size of SPIO nanocrystals.
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