期刊
ACS NANO
卷 6, 期 8, 页码 6862-6869出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn301670a
关键词
fluorescent magnetic nanoparticle; cancer targeting; magnetic targeting; molecular imaging; magnetic nanoparticle; fluorescent nanoparticle; nanoparticle theranostic agent
类别
资金
- NCI Center for Cancer Nanotechnology Excellence (CCNE) [1U54 CA119367-01]
- NIH Pathway to Independence Award [1K99E8008558-01]
- Stanford Molecular Imaging Scholars-NIH postdoctoral training grant
- Stanford Dean's Fellowship
Early detection and targeted therapy are two major challenges in the battle against cancer. Novel imaging contrast agents and targeting approaches are greatly needed to improve the sensitivity and specificity of cancer theranostic agents. Here, we implemented a novel approach using a magnetic micromesh and biocompatible fluorescent magnetic nanoparticles (FMN) to magnetically enhance cancer targeting in living subjects. This approach enables magnetic targeting of systemically administered individual FMN, containing a single 8 nm superparamagnetic iron oxide core. Using a human glioblastoma mouse model, we show that nanoparticles can be magnetically retained in both the tumor neovasculature and surrounding tumor tissues. Magnetic accumulation of nanoparticles within the neovasculature was observable by fluorescence intravital microscopy in real time. Finally, we demonstrate that such magnetically enhanced cancer targeting augments the biological functions of molecules linked to the nanoparticle surface.
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