期刊
ACS NANO
卷 6, 期 5, 页码 4157-4168出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn300652p
关键词
multicomponent nanoparticle; magnetic nanoparticles; radio-frequency-triggered drug release; doxorubicin; nanochain; chemotherapy
类别
资金
- American Cancer Society [IRG-91-022-18]
- Case Comprehensive Cancer Center [P30 CA043703]
- NIH [5T32EB007509]
While nanoparticles maximize the amount of chemotherapeutic drug In tumors relative to normal tissues, nanoparticle-based drugs are not accessible to the majority of cancer cells because nanoparticles display patchy, near-perivascular accumulation in tumors. To overcome the limitations of current drugs In their molecular or nanoparticle form, we developed a nanoparticle based on multicomponent nanochains to deliver drug to the majority of cancer cells throughout a tumor while reducing off-target delivery. The nanoparticle Is composed of three magnetic nanospheres and one doxorubicin-loaded liposome assembled In a 100 nm long chain. These nanoparticles display prolonged blood circulation and significant intratumoral deposition in tumor models In rodents. Furthermore, the magnetic particles of the chains serve as a mechanical transducer to transfer radio frequency energy to the drug-loaded liposome. The defects on the liposomal walls trigger the release of free drug capable of spreading throughout the entire tumor, which results In a widespread anticancer effect.
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