期刊
ACS NANO
卷 6, 期 8, 页码 6614-6625出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn302222m
关键词
MWCNT; microtubules; cell division; HeLa cell; cancer; apoptosis
类别
资金
- Spanish MICINN [MAT2011-28868-C02-01, BFU2010-18948]
- MALTA Consolider-Ingenio [CSD2007-00045]
- Centrosome-3D Consolider-Ingenio [CSD2006-00023]
Microtubules are hollow protein cylinders of 25 nm diameter which are implicated in cytokinetics and proliferation in all eukaryotic cells. Here we demonstrate in vivo how multiwalled carbon nanotubes (MWCNTs) Interact with microtubules in human cancer cells (HeLa) blocking mitosis and leading to cell death by apoptosis. Our data suggest that, inside the cells, MWCNTs display microtubule biomimetic properties, assisting and enhancing noncentrosomal microtubule polymerization and stabilization. These features might be useful for developing a revolutionary generation of chemotherapeutic agents based on nanomaterials.
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