期刊
ACS NANO
卷 6, 期 8, 页码 7295-7302出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn302413u
关键词
nanopore; nanoparticle; resistive-pulse technique; ion current
类别
资金
- National Science Foundation [CHE 0747237]
- UC National Lab Fee Program [09-LR-09-116432-SIWZ]
- U.S. Department of Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344]
- European Union FP7 Marie Curie Program [PIOF-GA-2008-220492]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0747237] Funding Source: National Science Foundation
In this article, we report resistive-pulse sensing experiments with cylindrical track-etched PET pores, which reveal that the diameters of these pores fluctuate along their length. The resistive pulses generated by polymer spheres passing through these pores have a repeatable pattern of large variations corresponding to these diameter changes. We show that this pattern of variations enables the unambiguous resolution of multiple particles simultaneously in the pore, that it can detect transient sticking of particles within the pore, and that it can confirm whether any individual particle completely translocates the pore. We demonstrate that nonionic surfactant has a significant impact on particle velocity, with the velocity decreasing by an order of magnitude for a similar increase in surfactant concentration. We also show that these pores can differentiate by particle size and charge, and we explore the influence of electrophoresis, electroosmosis, and pore size on particle motion. These results have practical importance for increasing the speed of resistive-pulse sensing, optimizing the detection of specific analytes, and identifying particle shapes.
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