期刊
ACS NANO
卷 5, 期 9, 页码 6962-6970出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn201446c
关键词
Paclitaxel; nanoparticle; DNA-gold; chemoresistance; nanomedicine; cancer
类别
资金
- Nanoscale Science and Engineering Initiative of the National Science Foundation [EEC-0647560]
- National Cancer Institute [U54CA151880]
- National Science Foundation [CMMI-0846323, CMMI-0856492]
- V Foundation for Cancer
- National Science Foundation Center for Scalable and Integrated NanoManufacturing (SINAM) [DMI-0327077]
- Wallace H. Coulter Foundation
- National Science Foundation National Center for Learning & Teaching in Nanoscale Science and Engineering (NCLT)
- National Institutes of Health [U54 A1065359]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [0846323] Funding Source: National Science Foundation
Paclitaxel, a potent chemotherapeutic utilized in a variety of cancers, can be limited In its effectiveness due to inherent insolubility in aqueous media and acquired chemoresistance within certain cells. An approach has been developed for increasing Paclitaxel solubility and effectiveness by covalent attachment to gold nano particles via DNA linkers. The resulting conjugates are highly soluble in aqueous buffer, exhibiting greater than a 50-fold increase in solubility over the unconjugated drug. DNA linkers are labeled with a fluorophore, which affords a convenient means of visualizing resultant conjugates within cells. Internalized conjugates demonstrate increased activity as compared with free drug across a variety of cell types, including a Paclitaxel-resistant cell line. Attachment to DNA-nanoparticle conjugates may become a general strategy for solubilizing and enhancing a wide variety of therapeutic agents in aqueous media.
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