期刊
ACS NANO
卷 5, 期 3, 页码 2356-2361出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn200091p
关键词
graphene; impedance spectroscopy; hairpin-DNA; genosensor; single nucleotide polymorphism
类别
资金
- NTU, Singapore [M58110000]
There is enormous need for sensitive and selective detection of single nucleotide polymorphism of a DNA strand as this issue is related to many major diseases and disorders, such as Parkinson's and Alzheimer's disease. To achieve sensitivity and selectivity of the detection, a highly sensitive transducer of the signal with high surface area is required. In this work we employ a graphene platform to combine the sensitivity of electrochemical Impedance spectroscopy with the high selectivity of hairpin shaped DNA probes for the rapid detection of single nucleotide polymorphism correlated to the development of Alzheimer's disease. We investigate the influence of various graphene platforms consisting of different numbers of same sized graphene layers. We believe that our findings are an important step toward highly sensitive and selective sensing architectures.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据